Post-Doctoral Associate-Tissue Resident Memory T Cells
University of Minnesota, Twin Cities
Location: Minneapolis, Minnesota
Internal Number: 343639
About the Job:
The project involves characterization of how calprotectin regulates the activity of CD69+ tissue residents T cells in a murine model of periodontitis. The functional interaction of calprotectin with CD69 on T cells will be characterized as regulating the extent of inflammation in the initial and chronic phases of murine experimental periodontitis. The successful applicant will be responsible for analyzing, organizing, and presenting data, drafting manuscripts, and making presentations. Finalization of all data, manuscripts and presentations will be done collaboratively with lab members and with approval of the PI.
CD69+ resident-memory T cell regulation: The CD69 receptor on tissue-resident antigen-experienced T cells binds several membrane-bound and soluble ligands. For example, CD69 engagement on T regulatory cells was reported to induce immunosuppressive activities. A putative natural ligand for CD69-mediated activation of Tregs is calprotectin. When released from infected or desquamating keratinocytes or neutrophils, calprotectin may interact with CD69+ T regulatory or T helper 17 cells, ultimately suppressing the immune response.
Restrictions: This position is initially limited to two years based on available R01 funds from NIH. Continued appointment is also contingent upon satisfactory performance. Extension for additional years will depend on productivity and on continued funding by the non-competing yearly renewal of the R01 award. Application for an NIH F-award within 6 months of appointment is strongly encouraged.
Degree and/or credentials: Ph.D., DDS, DVM, MD or equivalent is required
Experience with murine models of infection, culture of bacteria, flow cytometry, microdissection, immunoassays.
Excellent record keeping, scientific writing as evidenced by published manuscripts and ability to work independent and in a team
Strong interpersonal and organizational skills
Doctorate in relevant field including 1 to 5 years of research experience preferred
Collaboration within and outside of the laboratory is strongly encouraged
Previous experience in mucosal immunology studies is an asset but not required
Preferred specialties and skills:
Preference will be given to individuals with research experience in Langerhans cell and tissue-resident T cell biology, T cell activation, and protein-protein interactions
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.